ERTAPENEM PACKAGE INSERT PDF

For Package Inserts, please click on the NDC#. Presentation(s):1g; Reference Listed Drug:Invanz®; Therapeutic Class: Antibacterial, carbapenem type. INVANZ 1 g powder for concentrate for solution for infusion. 2. . This medicinal product contains approximately mEq (approximately mg) of sodium per g dose which should Package Leaflet: information for the user. INVANZ 1 . Product Availability · Contact Us · Make An Inquiry. () Product Summary. Ertapenem Sodium Injection. Therapeutic Class: Carbapenem Antibiotic.

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Theoretically, efflux activity plus loss of membrane permeability is less likely to happen in vivo than AmpC beta-lactamase expression and loss of membrane permeability.

Immediately withdraw the appropriate dose and inject deeply into a large ertapenwm i. Antibiotics are non-selective and may result in the eradication of beneficial microorganisms while promoting the emergence of undesired ones, causing secondary infections such as oral thrush, colitis, or vaginitis.

Ertapenem Sodium Injection – Par Sterile Products – Products

Do not co-infuse with other medications. The percentage of time required for both bacteriostatic and maximal bactericidal activity is different for the various classes of beta-lactams. Most patients with skin and soft tissue infections do well with 1 to 2 weeks of therapy. Ertapenem is excreted in human breast milk.

Guidelines recommend ertapenem for 4 to 7 days for community-acquired infections. Inhibition of vitamin K inaert due to alterations in the intestinal flora may be a mechanism; however, concurrent infection is also a potential risk factor for elevated INR. Ertapenem apckage a short PAE of 1. PBPs are responsible for several steps in the synthesis of the cell wall and are found in quantities of several packahe to several thousand molecules per bacterial cell.

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The MICs are defined for Enterobacteriaceae as susceptible at 0. Affected cytochrome P isoenzymes: PAE is defined as the suppression of bacterial growth that continues after the antibiotic concentration falls below the bacterial MIC. It was concluded that the antibiotics ampicillin, ciprofloxacin, clarithromycin, doxycycline, metronidazole, ofloxacin, roxithromycin, temafloxacin, and tetracycline did not alter plasma concentrations of Insedt.

In some instances, this effect is used therapeutically to increase availability of the antimicrobial agent. Additionally, increased monitoring of the INR, especially during initiation and upon discontinuation of the antibiotic, may be necessary.

May consider IM administration as an alternative to IV administration in the treatment of infections where IM therapy is appropriate; however, only administer via IM injection for 7 days. Consider transitioning to an appropriate oral therapy after at least 3 days of parenteral therapy, once clinical improvement has been demonstrated.

The concentration in breast milk 24 hours after a 1 g dose ranged from less than 0. Shake well to dissolve.

Ertapenem for Injection — AuroMedics Pharma LLC

Infants and Children 3 months to 12 years. Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. Immediately transfer the appropriate amount of the reconstituted vial to diluent.

Ertapenem, in combination with an agent for atypical pathogens, is considered an acceptable alternative beta-lactam alternative for hospitalized patients with risk factors for infection with gram-negative pathogens other than Pseudomonas aeruginosa. Another review concurred with these data, but noted that individual patients have been identified who experienced significant decreases in plasma concentrations of combined OC components and who appeared to ovulate; the agents most often associated with these changes were rifampin, tetracyclines, and penicillin derivatives.

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Patients who have experienced anaphylactic reactions to penicillins or cephalosporins should not receive ertapenem.

For the treatment of complicated skin and skin structure infections, including diabetic foot infections diabetic foot ulcer. PBPs vary among different bacterial species. Sodium picosulfate; Magnesium oxide; Anhydrous citric acid: In moderate to severe cases, fluids and electrolytes, protein supplementation, and treatment with an antibacterial effective against Clostridium difficile may be warranted.

According to OBRA, use of antibiotics should be limited to confirmed or suspected bacterial infections.

Ertapenem for Injection

By day 5 after discontinuation, the concentration in breast milk was undetectable. If ertapenem is given 6 hours or more prior to hemodialysis, no supplemental dosing is required. Guidelines recommend ertapenem for 4 to 7 days for mild-to-moderate community-acquired infections, including perforated insery abscessed appendicitis. Like meropenem, but unlike imipenem, it has a 1-beta-methyl substituent and does not require protection with an inhibitor of human renal dihydropeptidase I.